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4-Toluenesulfonyl chloride → HCID 22063579, 화합물

HRID 1828479
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HRID 1828479 반응식
O[C:2]1[N:3]=[C:4]2[CH:12]=[C:11]([CH2:13][CH2:14][C:15]3[S:16][CH:17]=[C:18]([CH:20]([CH3:22])[CH3:21])[N:19]=3)[CH:10]=[CH:9][N:5]2[C:6](=[O:8])[CH:7]=1.C(N(CC)CC)C.C1(C)C=CC(S(Cl)(=O)=O)=CC=1.[NH:41]1[CH2:46][CH2:45][O:44][CH2:43][CH2:42]1>C(Cl)Cl>[CH:20]([C:18]1[N:19]=[C:15]([CH2:14][CH2:13][C:11]2[CH:10]=[CH:9][N:5]3[C:6](=[O:8])[CH:7]=[C:2]([N:41]4[CH2:46][CH2:45][O:44][CH2:43][CH2:42]4)[N:3]=[C:4]3[CH:12]=2)[S:16][CH:17]=1)([CH3:22])[CH3:21]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 73974-Toluenesulfonyl chlorideHCID 8083MorpholineHCID 8471TriethylamineHCID 135749047HCID 135749047, 화합물2회

생성물 1

HCID 22063579HCID 22063579, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The 2-hydroxy-8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-4 H-pyrido[1,2-a]-pyrimidin-4-one (500 mg) obtained in (A) was dissolved in methylene chloride (20 ml), added with triethylamine (0.26 ml) and p-toluenesulfonyl chloride (360 mg) and stirred for 24 hours under nitrogen atmosphere. The reaction solution was added with morpholine (0.83 ml) and stirred for 12 hours, and the solvent was evaporated. The residue was purified by silica gel column chromatography to obtain the title compound (273 mg).

후처리

  1. stirringstirred for 12 hours
  2. customthe solvent was evaporated
  3. customThe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-621de2717764449ca017391d4323bb17
출처 데이터셋
uspto-grants-2006_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07056917B2

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