4-[(E)-2-(4-Isopropyl-1,3-thiazol-2-yl)-1-ethenyl]-2-pyridinamine → 2-Hydroxy-8-[(E)-2-(4-isopropyl-1,3-thiazol-2-yl)-1-ethenyl]-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 1828487노트

반응식

HRID 1828487 반응식
[CH:1]([C:4]1[N:5]=[C:6](/[CH:9]=[CH:10]/[C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH2:17])[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].[C:18](OC1C=CC(Cl)=C(Cl)C=1Cl)(=[O:23])[CH2:19][C:20]([O-])=[O:21]>C1(C)C=CC=CC=1>[OH:23][C:18]1[N:17]=[C:13]2[CH:12]=[C:11](/[CH:10]=[CH:9]/[C:6]3[S:7][CH:8]=[C:4]([CH:1]([CH3:3])[CH3:2])[N:5]=3)[CH:16]=[CH:15][N:14]2[C:20](=[O:21])[CH:19]=1

참가 물질

4

반응물 2

HCID 220635144-[(E)-2-(4-Isopropyl-1,3-thiazol-2-yl)-1-ethenyl]-2-pyridinamine2회HCID 22063717Trichlorophenyl malonate

생성물 1

HCID 1363468402-Hydroxy-8-[(E)-2-(4-isopropyl-1,3-thiazol-2-yl)-1-ethenyl]-4H-pyrido[1,2-a]pyrimidin-4-one수율 93%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

The 4-[(E)-2-(4-isopropyl-1,3-thiazol-2-yl)-1-ethenyl]-2-pyridinamine (2.65 g, 10.8 mmol) obtained in (D) was dissolved in toluene (100 ml), added with trichlorophenyl malonate (5.50 g, 11.9 mmol), and refluxed by heating for 1.5 hours. After the reaction mixture was concentrated, the deposited solid was collected by filtration and washed with n-hexane and ether to obtain the title compound (3.14 g, 93%) as yellow solid.

후처리

  1. temperaturerefluxed
  2. temperatureby heating for 1.5 hours
  3. concentrationAfter the reaction mixture was concentrated
  4. filtrationthe deposited solid was collected by filtration
  5. washwashed with n-hexane and ether

출처 및 근거

ORD 기록
ord-5595721567744e4c9c25b60897275712
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056917B2

반응 노트

불러오는 중…