4-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridine → 8-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-hydroxy-3-[(4-methoxybenzyl)tetrazol-5-yl]-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 1828510노트

반응식

HRID 1828510 반응식
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH2:17])[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].[CH3:18][O:19][C:20]1[CH:42]=[CH:41][C:23]([CH2:24][N:25]2[C:29]([CH:30]([C:36](OCC)=[O:37])[C:31](OCC)=[O:32])=[N:28][N:27]=[N:26]2)=[CH:22][CH:21]=1>BrC1C=CC=CC=1>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]3[C:31](=[O:32])[C:30]([C:29]4[N:25]([CH2:24][C:23]5[CH:41]=[CH:42][C:20]([O:19][CH3:18])=[CH:21][CH:22]=5)[N:26]=[N:27][N:28]=4)=[C:36]([OH:37])[N:17]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 220636524-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridineHCID 22063755Diethyl 2-[1-(4-methoxybenzyl)tetrazol-5-yl]malonate

생성물 1

HCID 1357244388-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-hydroxy-3-[(4-methoxybenzyl)tetrazol-5-yl]-4H-pyrido[1,2-a]pyrimidin-4-one수율 71.7%

시약·촉매·용매 1

HCID 7961Bromobenzene용매

실험 절차

4-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridine (50 mg) and diethyl 2-[1-(4-methoxybenzyl)tetrazol-5-yl]malonate (141 mg) were heated to 150° C. in bromobenzene with stirring for 4 hours. After the solvent was evaporated, the residue was purified by silica gel column chromatography to obtain the title compound (73 mg) as cream solid.

후처리

  1. customAfter the solvent was evaporated
  2. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-e16a421f5eee48ed99d233754d116ddb
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056917B2

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