Anisole → HCID 178439804, 화합물

HRID 1828513노트

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HRID 1828513 반응식
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:41]=[CH:40][N:14]3[C:15](=[O:39])[C:16]([C:25]4[N:29](CC5C=CC(OC)=CC=5)[N:28]=[N:27][N:26]=4)=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:41]=[CH:40][N:14]3[C:15](=[O:39])[C:16]([C:25]4[NH:29][N:28]=[N:27][N:26]=4)=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 7519AnisoleHCID 696031968-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl)-2-morpholino-3-(1-p-methoxybenzyl-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one2회

생성물 1

HCID 178439804HCID 178439804, 화합물수율 88.6%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

The 8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-3-(1-p-methoxybenzyl-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one (10 mg) obtained in (C) was dissolved in trifluoroacetic acid (1 ml) and added with anisole (50 ml), and then stirred at room temperature for 4 hours. After the solvent was evaporated, the residue was purified by silica gel column chromatography to obtain the title compound (7 mg) as yellow powder.

후처리

  1. customAfter the solvent was evaporated
  2. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-6a300be324554dae880183e637b2b981
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056917B2

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