Bromobenzene → ethyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate

HRID 1828514노트

반응식

HRID 1828514 반응식
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH2:17])[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].CN([CH:21]=[C:22]([C:30](OCC)=[O:31])[CH:23]=[CH:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])C.BrC1C=CC=CC=1>>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]3[C:30](=[O:31])[C:22](/[CH:23]=[CH:24]/[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:21][N:17]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 3

HCID 7961BromobenzeneHCID 220636524-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridineHCID 54366534Diethyl 1-dimethylamino-1,3-butadiene-2,4-dicarboxylate

생성물 1

HCID 86588142ethyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate수율 6.2%

반응 조건

온도
160 °C

실험 절차

4-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridine(200 mg), diethyl 4-dimethylaminomethyleneglutaconate (265 mg) was added with bromobenzene (2 ml) and heated at 120° C. for 1 hour and at 160° C. for 4 hours with stirring. The residue was purified by silica gel column chromatography to obtain the title compound (20 mg) as white powder.

후처리

  1. customThe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-8e1ee26a48b34949bd410e20598ecf71
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056917B2

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