N-(4-methyl-5-nitropyridin-2-yl)acetamide → N-(5-Amino-4-methylpyridin-2-yl)acetamide

HRID 1828541

반응식

HRID 1828541 반응식
[CH3:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][N:5]=[C:4]([NH:11][C:12](=[O:14])[CH3:13])[CH:3]=1>C(O)C.[Pd]>[NH2:8][C:7]1[C:2]([CH3:1])=[CH:3][C:4]([NH:11][C:12](=[O:14])[CH3:13])=[N:5][CH:6]=1

참가 물질

4

반응물 1

HCID 13567013N-(4-methyl-5-nitropyridin-2-yl)acetamide2회

생성물 1

HCID 22063573N-(5-Amino-4-methylpyridin-2-yl)acetamide수율 103%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The N1-(4-methyl-5-nitro-2-pyridyl)acetamide (4.70 g, 24.1 mmol) obtained in (A) was dissolved in ethanol (150 ml), added with 10% palladium/carbon (0.95 g) and subjected to catalytic reduction overnight at 1 atm under hydrogen atmosphere. The catalyst was removed by filtration and washed with ethanol. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography (chloroform chloroform:methanol=100:5) to obtain the title compound (4.10 g, quantitative) as brown solid.

후처리

  1. customsubjected to catalytic reduction overnight at 1 atm under hydrogen atmosphere
  2. customThe catalyst was removed by filtration
  3. washwashed with ethanol
  4. concentrationThe filtrate was concentrated
  5. customthe resulting residue was purified by silica gel column chromatography (chloroform chloroform:methanol=100:5)

출처 및 근거

ORD 기록
ord-ef9681cf549f4b29a9a1e54462238dc5
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056917B2

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