Benzene, 1-iodo-2-(trifluoromethyl)- → 1,1'-Biphenyl, 2,2'-bis(trifluoromethyl)-
반응식
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9]>[Cu].CN(C=O)C>[F:9][C:8]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9]참가 물질
4
실험 절차
To a 2-L three-necked, round-bottom flask fitted with a mechanical stirrer and a condenser was added 507.5 g of 2-iodotrifluoromethylbenzene (1.86 mol), 282.0 g of copper powder and 400 ml of DMF. The reaction mixture was stirred and heated at reflux for 24 hours and filtered. The filtrate was distilled under reduced pressure to yield 211.8 g (78%) of a light yellow oil.
후처리
- customTo a 2-L three-necked, round-bottom flask fitted with a mechanical stirrer and a condenser
- temperatureheated
- temperatureat reflux for 24 hours
- filtrationfiltered
- distillationThe filtrate was distilled under reduced pressure
출처 및 근거
- ORD 기록
- ord-b8b25c1aa56a4d11a472817993e8beff
- 출처 데이터셋
- uspto-grants-2006_06
- 특허 번호
- US07058249B2
반응 노트
불러오는 중…