Ethyl bromoacetate → HCID 17937805, 화합물

HRID 1828648노트

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HRID 1828648 반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[O:6][CH2:7][C:8](=[O:9])[C:4]=2[CH:3]=1.C([O-])([O-])=O.[K+].[K+].[CH2:18]([O:20][C:21](=[O:24])[CH2:22]Br)[CH3:19].CCCCCC>O1CCCC1.C(OCC)(=O)C>[CH2:18]([O:20][C:21]([CH2:22][O:1][C:2]1[CH:11]=[CH:10][C:5]2[O:6][CH2:7][C:8](=[O:9])[C:4]=2[CH:3]=1)=[O:24])[CH3:19]

참가 물질

7

반응물 4

HCID 7748Ethyl bromoacetateHCID 8058HexaneHCID 11430Potassium CarbonateHCID 99641425-Hydroxy-2,3-dihydro-1-benzofuran-3-one

생성물 1

HCID 17937805HCID 17937805, 화합물수율 98%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

3.00 g (20 mmol) XVIII, 3.96 g (40 mmol) K2CO3 and 5.54 ml (50 mmol) bromoacetic acid ethyl ester were heated under reflux for 72 h in 150 ml tetrahydrofuran. After filtration, the solvent was removed. Flash chromatography (200 g SiO2, n-hexane:ethyl acetate=2:1) produced 4.63 g (19.6 mmol, 98%) XIX.

후처리

  1. filtrationAfter filtration
  2. customthe solvent was removed

출처 및 근거

ORD 기록
ord-1c29ef35659044f586a51410615201bc
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07060109B2

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