1-Cyclohexyl-4-(4-methoxy-benzyloxymethyl)-2-trifluoromethyl-benzene → [4-Cyclohexyl-3-(trifluoromethyl)phenyl]methanol

HRID 1828703

반응식

HRID 1828703 반응식
[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][O:14]CC3C=CC(OC)=CC=3)=[CH:9][C:8]=2[C:24]([F:27])([F:26])[F:25])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)(C(F)(F)F)=O.C(Cl)Cl.CCOC(C)=O>[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][C:8]=2[C:24]([F:25])([F:26])[F:27])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

5

반응물 1

HCID 220577361-Cyclohexyl-4-(4-methoxy-benzyloxymethyl)-2-trifluoromethyl-benzene

생성물 1

HCID 22057748[4-Cyclohexyl-3-(trifluoromethyl)phenyl]methanol

시약·촉매·용매 3

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매HCID 8857Ethyl Acetate용매

실험 절차

The obtained 1-cyclohexyl-4-(4-methoxy-benzyloxymethyl)-2-trifluoromethyl-benzene is dissolved in a mixture of TFA and DCM (8 mL, 1:1 v/v). After stirring at room temperature for 2 h, all volatile materials are evaporated and the residue obtained is dissolved in EtOAc and washed with saturated aqueous NaHCO3. The organic layer is separated, washed with saturated aqueous NaCl and dried over Na2SO4. After concentration, the residue is purified by silica gel chromatography (20% ethyl acetate in hexanes) to give (4-cyclohexyl-3-trifluoromethyl-phenyl)-methanol as a colorless oil.

후처리

  1. customall volatile materials are evaporated
  2. customthe residue obtained
  3. washwashed with saturated aqueous NaHCO3
  4. customThe organic layer is separated
  5. washwashed with saturated aqueous NaCl
  6. dry with materialdried over Na2SO4
  7. concentrationAfter concentration
  8. customthe residue is purified by silica gel chromatography (20% ethyl acetate in hexanes)

출처 및 근거

ORD 기록
ord-0a86972aced5457e8484d1df143603d7
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07060697B2

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