Sodium Iodide → 4-(2-iodoethyl)morpholine
반응식
Cl.Cl[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.[I-:11].[Na+]>CC(C)=O>[I:11][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1참가 물질
4
실험 절차
A mixture of 4-(2-chloro-ethyl)-morpholine hydrochloride (5 g, 26.9 mmole), and sodium iodide (20 g, 134.4 mmole) in acetone (50 ml) was refluxed for 16 hours. After cooled to room temperature, the reaction was partitioned between CHCl3 and brine. The aqueous layer was extracted with CHCl3 (2×25 ml). The combined organic layers were washed with brine, and dried over anhydrous Mg2SO4. Removal of the solvent gave 4-(2-iodo-ethyl)-morpholine as a pale yellowish oil (3.84 g, 59%).
후처리
- temperaturewas refluxed for 16 hours
- customthe reaction was partitioned between CHCl3 and brine
- extractionThe aqueous layer was extracted with CHCl3 (2×25 ml)
- washThe combined organic layers were washed with brine
- dry with materialdried over anhydrous Mg2SO4
- customRemoval of the solvent
출처 및 근거
- ORD 기록
- ord-b5803652a742460cb752f359e2b504d5
- 출처 데이터셋
- uspto-grants-2006_06
- 특허 번호
- US07060844B2
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