참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethanolamine | HCID 8113 | — |
| 반응물 | 4-Chloro-2-(trifluoromethyl)quinoline | HCID 2736709 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | 4-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline | HCID 22028887 | — |
반응 단계
Diethanolamine (20 mL) was added to 4-chloro-2-trifluoromethylquinoline (5.04 g), and the mixture was stirred at 80° C. for 19 hr. Brine was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was dried and concentrated under reduced pressure. The residue was purified by silica gel chromatography to give 4-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline (3.40 g) as a white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07060722B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_06 |
|---|
| ORD ID | ord-5a12686d5b184c17957184f36a38ae38 |
|---|
| 출처 메모 | uspto-grants-2006_06 |
|---|
