4-Piperidinecarboxamide → benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate

HRID 1829166노트

반응식

HRID 1829166 반응식
[NH:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1.C(N(CC)CC)C.C(Cl)(=O)O[O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[C:29](=O)([O-])[OH:30].[Na+]>ClCCl>[CH2:20]([O:19][C:29]([N:1]1[CH2:9][CH2:8][CH:4]([C:5](=[O:6])[NH2:7])[CH2:3][CH2:2]1)=[O:30])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

참가 물질

6

반응물 4

HCID 37724-PiperidinecarboxamideHCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 21874344HCID 21874344, 화합물

생성물 1

HCID 2776131benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Isonipecotamide (19.4 g) and triethylamine (42 mL) were dissolved in dichloromethane (500 mL), and benzyloxy chlorocarbonate (24 mL) was added thereto under ice-cooling. The mixture was stirred at room temperature for 18 hr. The reaction mixture was added to saturated aqueous sodium hydrogencarbonate solution, and the mixture was extracted with chloroform. The extract was dried and concentrated under reduced pressure to give 1-benzyloxycarbonyl-4-carbamoylpiperidine (33.3 g) as a white solid.

후처리

  1. temperatureunder ice-cooling
  2. extractionthe mixture was extracted with chloroform
  3. customThe extract was dried
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-fd3beaac15bc45d7a3cb511b7ac6e72c
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07060722B2

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