Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Methyl((quinolin-3-yl)methyl)amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 3-Quinolinecarboxaldehyde | HCID 83641 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | Monomethylamine methanol | HCID 57454252 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl((quinolin-3-yl)methyl)amine | HCID 16494781 | 48.2% |
반응 단계
A solution of 3-quinolinecarboxaldehyde (1.5 g, 10 mmole), 2.0 M CH3NH2/MeOH (10 mL, 20 mmole), glacial AcOH (0.6 mL, 10 mmole), and NaBH3CN (0.35 g, 11 mmole) in MeOH (20 mL) was stirred at RT overnight, then was concentrated in vacuo. The residue was diluted with 5% NaOH and extracted with CH2Cl2. The combined organic extracts were washed with brine, dried over MgSO4, and concentrated. Flash chromatography on silica gel (10% MeOH/CH2Cl2) gave the title compound (0.83 g, 24%) as a slightly yellow viscous oil: MS (ES) m/e 173 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741339B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-72e0a1d798ad4dd1ba89fbb0b193a327 |
| 출처 메모 | uspto-grants-2010_06 |