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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1829800생성일: 2026년 10월 26일

phenylalaninol, (S)- → (S)-N-[1-benzyl-2-hydroxyethyl]-4-hydroxy-1-methyl-1H-indole-2-carboxamide

https://huagongshe.com/reaction/1829800

반응식

참여 물질

역할이름HCID투입량
반응물phenylalaninol, (S)-HCID 447213—
반응물4-Benzyloxy-1-methyl-1H-indole-2-carbonyl chlorideHCID 22054872—
생성물(S)-N-[1-benzyl-2-hydroxyethyl]-4-hydroxy-1-methyl-1H-indole-2-carboxamideHCID 69272852—
생성물(S)-N-[1-benzyl-2-hydroxyethyl]-4-(benzyloxy)-1-methyl-1H-indole-2-carboxamideHCID 69276702—

반응 단계

From (S)-2-amino-3-phenylpropan-1-ol and 4-benzyloxy-1-methyl-1H-indole-2-carbonyl chloride the intermediate compound (S)-N-[1-benzyl-2-hydroxyethyl]-4-(benzyloxy)-1-methyl-1H-indole-2-carboxamide was prepared by a method analogous to that described in Example 23. MS ES (M++H)=415. Hydrogenation of this intermediate by a method analogous to that described in Example 9 gave the title compound. MS ES (M++H)=325.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07064143B1
출처 데이터셋uspto-grants-2006_06
ORD IDord-6bb9a43d536b46ce973f4a40981662f4
출처 메모uspto-grants-2006_06