N-[2-(dimethylamino)ethyl]-6-nitro-1H-indole-2-carboxamide → 6-Amino-1H-indole-2-carboxylic acid (2-dimethylamino-ethyl)-amide

HRID 1829988노트

반응식

HRID 1829988 반응식
[CH3:1][N:2]([CH3:20])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][CH:13]=[C:12]([N+:17]([O-])=O)[CH:11]=2)=[O:7]>C(O)C.C(OC(=O)C)C.[Pd]>[CH3:1][N:2]([CH3:20])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][CH:13]=[C:12]([NH2:17])[CH:11]=2)=[O:7]

참가 물질

4

반응물 1

HCID 85801420N-[2-(dimethylamino)ethyl]-6-nitro-1H-indole-2-carboxamide

생성물 1

HCID 867597646-Amino-1H-indole-2-carboxylic acid (2-dimethylamino-ethyl)-amide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21584252Ethanol ethylacetate용매

실험 절차

To a solution of 82.9 mg (0.3 mmole) 125 in a mixture of ethanol/ethylacetate 1:1 10% Pd/C (40 mg) was added. The flask was flushed 3 times with hydrogen and filled with hydrogen at 30 to 35 psi. The suspension was stirred vigorously at room temperature for 30 minutes. The catalyst was filtered off, the filtrate was evaporated in vacuo to dryness. The solid 126 was used for the next step without purification.

후처리

  1. additionwas added
  2. customThe flask was flushed 3 times with hydrogen
  3. additionfilled with hydrogen at 30 to 35 psi
  4. filtrationThe catalyst was filtered off
  5. customthe filtrate was evaporated in vacuo to dryness
  6. customThe solid 126 was used for the next step without purification

출처 및 근거

ORD 기록
ord-c68aed6a0408449ca9c064e7987ffd55
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07064218B2

반응 노트

불러오는 중…