HCID 58650613, 화합물 → HCID 58650608, 화합물

HRID 1830005노트

반응식

HRID 1830005 반응식
[CH3:1][C@@H:2]1[N:7](CC2C=CC=CC=2)[CH2:6][C@@H:5]([CH2:15][N:16]([CH3:18])[CH3:17])[O:4][CH2:3]1>CCO.[Pd]>[CH3:1][C@@H:2]1[NH:7][CH2:6][C@@H:5]([CH2:15][N:16]([CH3:17])[CH3:18])[O:4][CH2:3]1

참가 물질

4

반응물 1

HCID 58650613HCID 58650613, 화합물

생성물 1

HCID 58650608HCID 58650608, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

반응 조건

온도
130 °C

실험 절차

{[(5S,2R)-5-methyl-4-benzylmorpholin-2-yl]methyl}dimethylamine (1 equivalent), was dissolved in EtOH and the solution was transferred to a stainless steel high pressure vessel equipped with a pressure gauge. 10% Pd/C was added (10 wt. %), and the vessel charged with H2. The reaction mixture was stirred at 130° C. and 200 psi of H2 overnight. The reaction mixture was cooled to room temperature, filtered over a pad of Celite, and then evaporated. The desired amine was obtained in quantitative yield as a pale yellow oil. GC/MS: 128 (10%, M+−2×CH3), 58 (100%, NHCH2CHO), Rt=8.16 minutes.

후처리

  1. customthe solution was transferred to a stainless steel high pressure vessel
  2. customequipped with a pressure gauge
  3. additionthe vessel charged with H2
  4. custom200 psi of H2 overnight
  5. temperatureThe reaction mixture was cooled to room temperature
  6. filtrationfiltered over a pad of Celite
  7. customevaporated

출처 및 근거

ORD 기록
ord-a23367ba38b3409ca0fbf181a92016c3
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07064215B2

반응 노트

불러오는 중…