Ethanol → HCID 12084327, 화합물

HRID 1830488노트

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HRID 1830488 반응식
[CH:1]([C:4]1[CH:16]=[CH:15][C:14]2[C:13]3[C:8](=[C:9]([F:17])[CH:10]=[CH:11][CH:12]=3)[CH2:7][C:6]=2[C:5]=1[F:18])=[CH:2][CH3:3].C(O)C>[C].[Pd].C1(C)C=CC=CC=1>[CH2:1]([C:4]1[CH:16]=[CH:15][C:14]2[C:13]3[C:8](=[C:9]([F:17])[CH:10]=[CH:11][CH:12]=3)[CH2:7][C:6]=2[C:5]=1[F:18])[CH2:2][CH3:3]

참가 물질

5

반응물 2

HCID 702EthanolHCID 69530634HCID 69530634, 화합물

생성물 1

HCID 12084327HCID 12084327, 화합물수율 43.7%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 1140Toluene용매

실험 절차

A mixture of 19.3 g of 2-(propen-1-yl)-1,8-difluorofluorene (K-3) (crude product), 1.5 g of 5% palladium-carbon, 80 ml of ethanol and 80 ml of toluene was hydrogenated over an 8 hour period at room temperature and under atmospheric pressure, with constant stirring. The palladium-carbon was removed by filtration, the solvent was removed from the filtrate by evaporation under reduced pressure, and the residue was then purified by silica gel column chromatography (hexane) to yield 8.5 g of 2-propyl-1,8-difluorofluorene (K-4).

후처리

  1. customThe palladium-carbon was removed by filtration
  2. customthe solvent was removed from the filtrate by evaporation under reduced pressure
  3. customthe residue was then purified by silica gel column chromatography (hexane)

출처 및 근거

ORD 기록
ord-44b82ba1755b41a1aec090d99e648d21
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067179B1

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