Chlorosuccinimide → 2-Amino-5-Chloro-alpha-(Methoxyimino)-4-Thiazoleacetic Acid

HRID 1830497노트

반응식

HRID 1830497 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH3:13])[C:8]([OH:10])=[O:9])[N:6]=1.[Cl:14]N1C(=O)CCC1=O>CN(C=O)C>[NH2:1][C:2]1[S:3][C:4]([Cl:14])=[C:5]([C:7](=[N:11][O:12][CH3:13])[C:8]([OH:10])=[O:9])[N:6]=1

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 1252162-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid

생성물 1

HCID 540093662-Amino-5-Chloro-alpha-(Methoxyimino)-4-Thiazoleacetic Acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 500 mL of DMF were added 50.0 g (250 mmol) of 2-amino-α-(methoxyimino)-4-thiazoleacetic acid and 35 g (260 mmol) of N-chlorosuccinimide. The mixture was stirred at room temperature overnight, after which time mass spectral analysis showed no more starting material to be present. The light brown solution was used without further manipulation.

출처 및 근거

ORD 기록
ord-e60286f54333406e9d02be34607a6a4f
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067481B2

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