2,6-Difluorobenzenesulfonyl chloride → N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-2,6-difluorobenzenesulfonamide

반응식

[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[c:18]([F:25])[c:19]([NH2:24])[cH:20][cH:21][c:22]3[F:23])[n:10][c:11]([C:13]([CH3:14])([CH3:15])[CH3:16])[s:12]2)[n:7]1.[F:26][c:27]1[c:28]([S:34](=[O:35])(=[O:36])[Cl:37])[c:29]([F:33])[cH:30][cH:31][cH:32]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[c:18]([F:25])[c:19]([NH:24][S:34]([c:28]4[c:27]([F:26])[cH:32][cH:31][cH:30][c:29]4[F:33])(=[O:35])=[O:36])[cH:20][cH:21][c:22]3[F:23])[n:10][c:11]([C:13]([CH3:14])([CH3:15])[CH3:16])[s:12]2)[n:7]1

참가 물질

반응물 2

HCID 27342712,6-Difluorobenzenesulfonyl chloride

HCID 57989911{3-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}amine

생성물 1

HCID 57989829N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-2,6-difluorobenzenesulfonamide

출처 및 근거

ORD 기록: ord-c86987032d2e4dee936a379581fd4092
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

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