3-(3-Chlorophenyl)-alpha-(4-phenyl-2-thiazolyl)-2,1-benzisoxazole-5-methanol → HCID 22048460, 화합물

HRID 1830803노트

반응식

HRID 1830803 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:9][N:10]=[C:11]3[CH:16]=[CH:15][C:14]([CH:17]([C:19]4[S:20][CH:21]=[C:22]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)[N:23]=4)[OH:18])=[CH:13][C:12]=23)[CH:5]=[CH:6][CH:7]=1>O1CCOCC1.O=[Mn]=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:9][N:10]=[C:11]3[CH:16]=[CH:15][C:14]([C:17]([C:19]4[S:20][CH:21]=[C:22]([C:24]5[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=5)[N:23]=4)=[O:18])=[CH:13][C:12]=23)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 220484773-(3-Chlorophenyl)-alpha-(4-phenyl-2-thiazolyl)-2,1-benzisoxazole-5-methanol

생성물 1

HCID 22048460HCID 22048460, 화합물수율 100%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 312751,4-Dioxane용매

반응 조건

온도
80 °C

실험 절차

A mixture of intermediate (14) (0.0656 mol) and MnO2 (27.5 g) in 1,4-dioxane (275 ml) was stirred at 80° C. for 3 hours, then cooled to room temperature, filtered over celite and pasted up with CH2Cl2/CH3OH. The solvent was evaporated till dryness, yielding 27.3 g (100%) of [3-(3-chlorophenyl)-2,1-benzisoxazol-5-yl](4-phenyl-2-thiazolyl)-methanone (intermediate 15).

후처리

  1. temperaturecooled to room temperature
  2. filtrationfiltered over celite
  3. customThe solvent was evaporated till dryness

출처 및 근거

ORD 기록
ord-d72d3f3bb9c442be9700e0c7f5b3bb0b
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067531B2

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