4-Chloro-nicotinonitrile → 4-Methoxy-nicotinonitrile

HRID 1830859노트

반응식

HRID 1830859 반응식
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[CH:4][CH:3]=1.[CH3:10][O-:11].[Na+].CO>CO>[CH3:10][O:11][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 134111124-Chloro-nicotinonitrileHCID 23694274Sodium methanolate methanol

생성물 1

HCID 27558874-Methoxy-nicotinonitrile수율 86%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of compound (20)(2.77 g, 20.0 mmol) in methanol (5 ml) was added a 28% sodium methylate-methanol solution (5.0 g, 24.0 mmol) at room temperature and the mixture was stirred for one hr. The solvent was concentrated and the obtained residue was partitioned between ethyl acetate and iced-brine. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The obtained residue was recrystallized from a small amount of isopropyl ether to give the title compound (2.3 g, 86%).

후처리

  1. concentrationThe solvent was concentrated
  2. customthe obtained residue was partitioned between ethyl acetate
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure
  5. customThe obtained residue was recrystallized from a small amount of isopropyl ether

출처 및 근거

ORD 기록
ord-0455b632e971400ca5ad7073ae0221fb
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067537B2

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