4-Vinylnicotinonitrile → 4-Ethylpyridine-3-carbonitrile

HRID 1830861노트

반응식

HRID 1830861 반응식
[CH:1]([C:3]1[C:8]([C:9]#[N:10])=[CH:7][N:6]=[CH:5][CH:4]=1)=[CH2:2]>C(OCC)(=O)C.[C].[Pd]>[CH2:1]([C:3]1[C:8]([C:9]#[N:10])=[CH:7][N:6]=[CH:5][CH:4]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 220497874-Vinylnicotinonitrile

생성물 1

HCID 217660084-Ethylpyridine-3-carbonitrile수율 84%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8857Ethyl Acetate용매

실험 절차

The compound (25) (0.73 g, 5.61 mmol) was dissolved in ethyl acetate (15 ml) and 10% palladium carbon (20 mg) was added. The mixture was stirred at normal temperature and normal pressure under a hydrogen atmosphere for 2 hrs. for hydrogenation. The reaction mixture was passed through celite and the filtrate was partitioned between ethyl acetate and brine. The aqueous layer was extracted with ethyl acetate, and the extract was combined and dried (MgSO4). The solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give a colorless oil (0.62 g, 84%).

후처리

  1. customthe filtrate was partitioned between ethyl acetate and brine
  2. extractionThe aqueous layer was extracted with ethyl acetate
  3. dry with materialdried (MgSO4)
  4. customThe solvent was evaporated under reduced pressure
  5. customThe obtained residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-b925a0658e7f49edae20a39078f518b4
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067537B2

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