Methylamine → 3-Cyano-N-methylbenzamide

HRID 1830874노트

반응식

HRID 1830874 반응식
[CH3:1][NH2:2].[C:3]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8](Cl)=[O:9])#[N:4]>C1COCC1>[C:3]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([NH:2][CH3:1])=[O:9])#[N:4]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 3084833-Cyanobenzoyl chloride

생성물 1

HCID 220496963-Cyano-N-methylbenzamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
5 °C

실험 절차

A mixture of 40% aqueous methylamine solution (20 ml) and THF (30 ml) was cooled to 5° C., and 3-cyanobenzoyl chloride (1.89 g) was slowly added. The mixture was stirred for one hr. The reaction mixture was extracted with ethyl acetate, and the organic layer was dried and concentrated. The residue was recrystallized from ethyl acetate to give the title compound (1.14 g) as colorless needle crystals.

후처리

  1. extractionThe reaction mixture was extracted with ethyl acetate
  2. customthe organic layer was dried
  3. concentrationconcentrated
  4. customThe residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-f0ba064e98704e17b2865c55a6045f08
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067537B2

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