3-Sulfamoylbenzene-1-carbothioamide → 3-[4-(4-Ethylpyridin-3-yl)-1,3-thiazol-2-yl]benzenesulfonamide

반응식

Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH2:11][CH3:12])=O.[NH2:13][S:14]([C:17]1[CH:18]=[C:19]([C:23](=[S:25])[NH2:24])[CH:20]=[CH:21][CH:22]=1)(=[O:16])=[O:15]>>[CH2:11]([C:10]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:3]1[N:24]=[C:23]([C:19]2[CH:18]=[C:17]([S:14]([NH2:13])(=[O:15])=[O:16])[CH:22]=[CH:21][CH:20]=2)[S:25][CH:2]=1)[CH3:12]

참가 물질

반응물 2

HCID 51512363-Sulfamoylbenzene-1-carbothioamide

HCID 220497942-Bromo-1-(4-ethylpyridin-3-yl)ethanone

생성물 1

HCID 220497743-[4-(4-Ethylpyridin-3-yl)-1,3-thiazol-2-yl]benzenesulfonamide수율 38.1%

실험 절차

By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-ethylpyridin-3-yl)ethanone hydrobromate (161 mg) and 3-(aminosulfonyl)benzenecarbothioamide (110 mg), the title compound (67 mg) was obtained as colorless powder crystals.

후처리

customBy the reaction in the same manner as in Example 25-iii)

출처 및 근거

ORD 기록: ord-762e0dbfe02f4eb6b64ad1d87825bcae
출처 데이터셋: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07067537B2

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