4-Sulfamoylthiobenzamide → 4-[4-(4-Ethylpyridin-3-yl)-1,3-thiazol-2-yl]benzenesulfonamide

HRID 1830912

반응식

HRID 1830912 반응식
Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH2:11][CH3:12])=O.[NH2:13][S:14]([C:17]1[CH:22]=[CH:21][C:20]([C:23](=[S:25])[NH2:24])=[CH:19][CH:18]=1)(=[O:16])=[O:15]>>[CH2:11]([C:10]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:3]1[N:24]=[C:23]([C:20]2[CH:19]=[CH:18][C:17]([S:14]([NH2:13])(=[O:15])=[O:16])=[CH:22][CH:21]=2)[S:25][CH:2]=1)[CH3:12]

참가 물질

3

반응물 2

HCID 30032664-SulfamoylthiobenzamideHCID 220497942-Bromo-1-(4-ethylpyridin-3-yl)ethanone

생성물 1

HCID 220497174-[4-(4-Ethylpyridin-3-yl)-1,3-thiazol-2-yl]benzenesulfonamide수율 51.7%

실험 절차

By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-ethylpyridin-3-yl)ethanone hydrobromate (161 mg) and 4-(aminosulfonyl)benzenecarbothioamide (109 mg), the title compound (90 mg) was obtained as colorless powder crystals.

후처리

  1. customBy the reaction in the same manner as in Example 25-iii)

출처 및 근거

ORD 기록
ord-285cfd6580484f57bad9d004f8256596
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067537B2

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