4-(Trifluoromethyl)pyridine-3-carbothioamide → HCID 22049737, 화합물

반응식

Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]([Br:12])[CH:6]=1)=O.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[CH:19][N:18]=[CH:17][C:16]=1[C:21](=[S:23])[NH2:22]>>[Br:12][C:7]1[CH:6]=[C:5]([C:3]2[N:22]=[C:21]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][C:15]=3[C:14]([F:25])([F:13])[F:24])[S:23][CH:2]=2)[CH:10]=[CH:9][C:8]=1[F:11]

참가 물질

반응물 2

HCID 27777714-(Trifluoromethyl)pyridine-3-carbothioamide

HCID 27827832,3'-Dibromo-4'-fluoroacetophenone

생성물 1

HCID 22049737HCID 22049737, 화합물수율 41%

실험 절차

By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(3-bromo-4-fluorophenyl)ethanone (3.10 g) and 4-trifluoromethylpyridine-3-thiocarboxamide (1.87 g), the title compound (1.50 g) was obtained as brown needle crystals.

후처리

customBy the reaction in the same manner as in Example 25-iii)

출처 및 근거

ORD 기록: ord-f602b7b88b024fa5843c47a68e206547
출처 데이터셋: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07067537B2

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