tert-Butyldimethylsilyl chloride → HCID 22047954, 화합물

HRID 1831060노트

반응식

HRID 1831060 반응식
[Si:1](Cl)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[OH:9][CH:10]1[CH2:15][CH2:14][N:13]([C:16]([N:18]2[CH:22]=[CH:21][N:20]=[CH:19]2)=[O:17])[CH2:12][CH2:11]1>CN(C)C=O>[C:4]([Si:1]([CH3:3])([CH3:2])[O:9][CH:10]1[CH2:15][CH2:14][N:13]([C:16]([N:18]2[CH:22]=[CH:21][N:20]=[CH:19]2)=[O:17])[CH2:12][CH2:11]1)([CH3:7])([CH3:6])[CH3:5]

참가 물질

4

반응물 2

HCID 28928tert-Butyldimethylsilyl chlorideHCID 22047711(4-Hydroxy-piperidin-1-yl)-imidazol-1-yl-methanone

생성물 1

HCID 22047954HCID 22047954, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

tert-Butyldimethylsilyl chloride (30.14 g, 0.20 mol) was added to a stirred solution of (4-hydroxy-piperidin-1-yl)-imidazol-1-yl-methanone (39.05 g, 0.20 mol) in dimethylformamide (200 mL). After stirring for 3 days at room temperature, the solvent was removed by evaporation in vacuo. The residue was redissolved in dichloromethane, extracted twice with water, dried over sodium sulphate, filtered and evaporated in vacuo, yielding the title compound, which was used without further purification.

후처리

  1. customthe solvent was removed by evaporation in vacuo
  2. dissolutionThe residue was redissolved in dichloromethane
  3. extractionextracted twice with water
  4. dry with materialdried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-0d3263e0e4f84ef49d20f6da1017f5e2
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067517B2

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