Pyridinium chloride → 2(1H)-Pyridinone, 5-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-

HRID 1831072

반응식

HRID 1831072 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=2)=[CH:5][N:4]=1.Cl.N1C=CC=CC=1>ClCCl>[F:19][C:16]([F:17])([F:18])[C:13]1[CH:14]=[CH:15][C:10]([O:9][C:6]2[CH:7]=[CH:8][C:3]([OH:2])=[N:4][CH:5]=2)=[N:11][CH:12]=1

참가 물질

4

반응물 2

HCID 10176127Pyridinium chlorideHCID 22047745Pyridine, 2-[(6-methoxy-3-pyridinyl)oxy]-5-(trifluoromethyl)-

생성물 1

HCID 1785162742(1H)-Pyridinone, 5-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-수율 68%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
200 °C

실험 절차

A mixture of 2-methoxy-5-(5-trifluoromethyl-pyridin-2-yloxy)-pyridine (0.28 g, 1.04 mmol) and pyridine hydrochloride (1.00 g, 8.65 mmol) was heated in a kugelrohr oven at 200° C. for 10 minutes. After cooling to room temperature, the reaction mixture is dissolved in dichloromethane and extracted with water, dried over sodium sulphate, filtered and evaporated in vacuo, yielding the title compound (180 mg, 68% yield) as a white solid.

후처리

  1. temperatureAfter cooling to room temperature
  2. extractionextracted with water
  3. dry with materialdried over sodium sulphate
  4. filtrationfiltered
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-fc869a2efc724db9817acdd4c72124b4
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067517B2

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