Triethylamine → (R)-(4-Chloro-3-nitropyridin-2-yl)-(1-methoxymethyl-propyl)-amine

HRID 1831575노트

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HRID 1831575 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[CH:5]=[CH:4][N:3]=1.CCN(CC)CC.[CH3:19][O:20][CH2:21][C@H:22]([NH2:25])[CH2:23][CH3:24]>CCO>[Cl:11][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([NH:25][C@@H:22]([CH2:21][O:20][CH3:19])[CH2:23][CH3:24])[C:7]=1[N+:8]([O-:10])=[O:9]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 105357732,4-Dichloro-3-nitropyridineHCID 210356842-Butanamine, 1-methoxy-, (2R)-

생성물 1

HCID 69658092(R)-(4-Chloro-3-nitropyridin-2-yl)-(1-methoxymethyl-propyl)-amine수율 155.4%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
60 °C

실험 절차

2,4-Dichloro-3-nitropyridine (1.0 g, 5,18 mmol) was dissolved in EtOH (20 mL), followed by the addition of Et3N (1.05 g, 10.4 mmol) and (R)-1-methoxymethyl-propylamine (0.72 g, 5.18 mmol) and the reaction was heated at 60° C. for 3 h. The reaction was concentrated in vacuo to yield 2.09 g of (R)-(4-chloro-3-nitro-pyridin-2-yl)-(1-methoxymethyl-propyl)-amine as a crude viscous oil: MS (AP) m/z 259.69 [(M+H)+, 97].

후처리

  1. concentrationThe reaction was concentrated in vacuo

출처 및 근거

ORD 기록
ord-a485b3e43d9045a3a396e5691b1ad9f3
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067658B2

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