Trifluoroacetic acid → [1-[5-(Trichloromethyl)-1,2,4-oxadiazol-3-yl]piperidin-4-yl]methanamine;2,2,2-trifluoroacetic acid

HRID 1831803노트

반응식

C(OC(=O)[NH:7][CH2:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[N:19]=[C:18]([C:20]([Cl:23])([Cl:22])[Cl:21])[O:17][N:16]=2)[CH2:11][CH2:10]1)(C)(C)C.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>>[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].[Cl:23][C:20]([Cl:21])([Cl:22])[C:18]1[O:17][N:16]=[C:15]([N:12]2[CH2:13][CH2:14][CH:9]([CH2:8][NH2:7])[CH2:10][CH2:11]2)[N:19]=1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 23396323[1-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-piperidin-4-ylmethyl]-carbamic acid tert-butyl ester

생성물 1

HCID 86586945[1-[5-(Trichloromethyl)-1,2,4-oxadiazol-3-yl]piperidin-4-yl]methanamine;2,2,2-trifluoroacetic acid

실험 절차

[1-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-piperidin-4-ylmethyl]-carbamic acid tert-butyl ester (500 mg, 1.25 mmol) and 30% aqueous trifluoro-acetic acid (5 ml) were stirred for 24 hours at room temperature. The mixture was evaporated and lyophilised. The product contains excess of trifluoro-acetic acid.

후처리

customThe mixture was evaporated

출처 및 근거

ORD 기록: ord-e1c41654222f4d9fb3b8b7bc5135a3db
출처 데이터셋: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07067665B2

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