4-benzyloxy-1-(3-fluorobenzyl)-1H-pyridin-2-one → HCID 54724162, 화합물

HRID 1831903노트

반응식

HRID 1831903 반응식
C([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)[C:11](=[O:23])[CH:10]=1)C1C=CC=CC=1>C(O)C>[F:22][C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][CH:19]=1)[CH2:15][N:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]1=[O:23]

참가 물질

3

반응물 1

HCID 220502224-benzyloxy-1-(3-fluorobenzyl)-1H-pyridin-2-one

생성물 1

HCID 54724162HCID 54724162, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In a Fischer-Porter bottle, added a solution of 4-(benzyloxy)-1-(3-fluorobenzyl)pyridin-2(1H)-one (4.5 g, 14.56 mmol) in absolute ethanol-(20 mL). Flushed the solution with nitrogen then added palladium catalyst (1.05 g). Sealed bottle and evacuated system. The system was purged with hydrogen gas (2×15 psi) to check for leaks. The reaction was charged with hydrogen (35 psi) and stirred at room temperature for 45 min. The system was evacuated and flushed with nitrogen. The reaction was filtered and the catalyst was carefully washed with fresh ethanol. The filtrate was concentrated under reduced pressure.

후처리

  1. customFlushed the solution with nitrogen
  2. customSealed bottle
  3. customevacuated system
  4. customThe system was purged with hydrogen gas (2×15 psi)
  5. additionThe reaction was charged with hydrogen (35 psi)
  6. customThe system was evacuated
  7. customflushed with nitrogen
  8. filtrationThe reaction was filtered
  9. washthe catalyst was carefully washed with fresh ethanol
  10. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c4bb582f305842b0b53556a4f1ff4944
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067540B2

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