Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromine → 3-bromo-4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one | HCID 22050390 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 3-bromo-4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one | HCID 22050832 | 102.1% |
반응 단계
To an ice-cold solution of 4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one (0.75 g, 3.1 mmol) in AcOH (12 mL) was added a solution of bromine (0.2 mL, 3.5 mmol) in AcOH (6 mL), and the reaction mixture was stirred 10 min. The solvent was removed under reduced pressure to afford 3-bromo-4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one as a white solid (1.0 g, 100%): ESI MS m/z 299 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07067540B2 |
| 출처 데이터셋 | uspto-grants-2006_06 |
| ORD ID | ord-0406c07f8505478b8c22aae4b971f455 |
| 출처 메모 | uspto-grants-2006_06 |