1,1'-Carbonyldiimidazole → HCID 22049200, 화합물
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH2:14])[C:10]([CH3:13])([OH:12])[CH3:11])[CH:5]=[CH:6][C:7]=1[F:8].[C:15](N1C=CN=C1)(N1C=CN=C1)=[O:16]>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:10]([CH3:11])([CH3:13])[O:12][C:15](=[O:16])[NH:14]2)[CH:5]=[CH:6][C:7]=1[F:8]참가 물질
4
실험 절차
A mixture of 1-(3,4-difluorophenyl)-2-methyl-2-hydroxypropylamine (3.00 g, 14.9 mmol) and carbonyldiimidazole (2.418 g, 14.9 mmol) in dichloromethane (150 mL) was heated at reflux temperature for 36 h and the solvent evaporated. The residue was purified by column chromatography on silica gel using chloroform/ethyl acetate (9:1) to give the product as a viscous oil which solidified on standing (1.80 g, 50% yield). The product was used in the next step without further characterization.
후처리
- temperaturewas heated
- temperatureat reflux temperature for 36 h
- customthe solvent evaporated
- customThe residue was purified by column chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-e8ff5e32a0f24432931efe60a52d3374
- 출처 데이터셋
- uspto-grants-2006_06
- 특허 번호
- US07067534B1
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