3-(3-(Trifluoromethyl)phenoxy)benzaldehyde → 2-methyl-N-[3-(1-{3-[3-(trifluoromethyl)phenoxy]benzyl}-4-piperidinyl)phenyl]-propanamide

HRID 1832362노트

반응식

HRID 1832362 반응식
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[O:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[CH:10]=O.[CH3:20][CH:21]([CH3:37])[C:22]([NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH:26]=1)=[O:23]>>[CH3:20][CH:21]([CH3:37])[C:22]([NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]2[CH2:36][CH2:35][N:34]([CH2:10][C:9]3[CH:12]=[CH:13][CH:14]=[C:7]([O:6][C:5]4[CH:15]=[CH:16][CH:17]=[C:3]([C:2]([F:19])([F:18])[F:1])[CH:4]=4)[CH:8]=3)[CH2:33][CH2:32]2)[CH:26]=1)=[O:23]

참가 물질

3

반응물 2

HCID 5227113-(3-(Trifluoromethyl)phenoxy)benzaldehydeHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

생성물 1

HCID 167566382-methyl-N-[3-(1-{3-[3-(trifluoromethyl)phenoxy]benzyl}-4-piperidinyl)phenyl]-propanamide

실험 절차

Prepared by Procedure F and Scheme R using 3-[3-(trifluoromethyl)phenoxy]benzaldehyde and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 497.2 (M+H)+.

후처리

  1. customPrepared by Procedure F and Scheme R

출처 및 근거

ORD 기록
ord-96247fdd8e904347a6ba71d6b00e013d
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067534B1

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