2-(4-Chlorophenoxy)pyridine-3-carbonyl chloride → 2-(4-Chlorophenoxy)-N-(4-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}butyl)nicotinamide
반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:13]=[C:14]([NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21])[CH:15]=[CH:16][CH:17]=2)[CH2:8][CH2:7]1.[Cl:24][C:25]1[CH:40]=[CH:39][C:28]([O:29][C:30]2[N:38]=[CH:37][CH:36]=[CH:35][C:31]=2[C:32](Cl)=[O:33])=[CH:27][CH:26]=1>C1COCC1.C(Cl)Cl>[Cl:24][C:25]1[CH:26]=[CH:27][C:28]([O:29][C:30]2[N:38]=[CH:37][CH:36]=[CH:35][C:31]=2[C:32]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[CH2:7][CH2:8][CH:9]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([NH:18][C:19](=[O:23])[CH:20]([CH3:21])[CH3:22])[CH:13]=3)[CH2:10][CH2:11]2)=[O:33])=[CH:39][CH:40]=1참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
Prepared by Procedure Q2 (THF/DCM, 1:3) and Scheme AT using N-{3-[1-(4-aminobutyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 2-(4-chlorophenoxy)nicotinoyl chloride: ESMS m/e: 549.0 (M+H)+.