Butylamine → N-Butyl-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-amine

반응식

Cl[C:2]1[C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:6]=2[N:5]2[N:12]=[C:13]([CH3:15])[CH:14]=[C:4]2[N:3]=1.[CH2:16]([NH2:20])[CH2:17][CH2:18][CH3:19]>>[CH2:16]([NH:20][C:2]1[C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:6]=2[N:5]2[N:12]=[C:13]([CH3:15])[CH:14]=[C:4]2[N:3]=1)[CH2:17][CH2:18][CH3:19]

참가 물질

반응물 2

HCID 8007Butylamine

HCID 213891855-Chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine

생성물 1

HCID 21389188N-Butyl-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-amine

실험 절차

2.2 g. of 5-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine of Example 18 are refluxed in 10 ml. of n-butylamine for 12 hours. The excess amine is evaporated and the residue treated with 10 ml. of water. N-Butyl-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-amine is filtered off, yield: 2 g. (80%); m.p. 116.1° (methanol).

후처리

customThe excess amine is evaporated
additionthe residue treated with 10 ml
filtrationN-Butyl-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-amine is filtered off

출처 및 근거

ORD 기록: ord-ac054abd91924b8ea2013aa473bbef05
출처 데이터셋: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04066645

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