Ammonia → 2-Nicotinoyl-1-methylvinylamine

HRID 1833712노트

반응식

HRID 1833712 반응식
[C:1]([CH2:9][C:10](=O)[CH3:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[NH3:13]>C(O)C>[C:1]([CH:9]=[C:10]([NH2:13])[CH3:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 3001601-(Pyridin-3-yl)butane-1,3-dione

생성물 1

HCID 706189932-Nicotinoyl-1-methylvinylamine수율 91%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
50 °C

실험 절차

7.5 g of nicotinoyl-acetone are dissolved in 45 ml of anhydrous ethanol and, after adding 20 ml of ammonia, the mixture is then stirred for 3 days at 50° C in an autoclave. Concentrating the clear solution leaves an oil which becomes solid after a short time. After recrystallisation from toluene, 2-nicotinoyl-1-methylvinylamine (melting point 82°) is obtained in a 91% yield.

후처리

  1. concentrationConcentrating the clear solution
  2. customleaves an oil which
  3. customAfter recrystallisation from toluene

출처 및 근거

ORD 기록
ord-8a207e90208d4bf18f87256fff1b751c
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04066768

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