Sodium ethoxide → 4-(4-n-Heptylpyrimid-2-yl)-benzoic acid

HRID 1833716노트

반응식

HRID 1833716 반응식
Cl.[CH2:2]([O:4][C:5](=[O:15])[C:6]1[CH:11]=[CH:10][C:9]([C:12](=[NH:14])[NH2:13])=[CH:8][CH:7]=1)[CH3:3].[CH2:16]([C:23](=[CH:26]OCC)C=O)[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].[CH3:30]C[O-].[Na+]>CO>[CH2:2]([O:4][C:5](=[O:15])[C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:23]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH:26]=[CH:30][N:14]=2)=[CH:8][CH:7]=1)[CH3:3].[CH2:17]([C:16]1[CH:23]=[CH:26][N:13]=[C:12]([C:9]2[CH:8]=[CH:7][C:6]([C:5]([OH:4])=[O:15])=[CH:11][CH:10]=2)[N:14]=1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:30]

참가 물질

6

반응물 3

HCID 2723922Sodium ethoxideHCID 12710118Benzoic acid, 4-(aminoiminomethyl)-, ethyl ester, hydrochloride (1:1)HCID 542398243-Ethoxy-2-heptylacrolein

생성물 2

HCID 203796744-(4-n-Heptylpyrimid-2-yl)-benzoic acidHCID 543719414(4-n-Heptylpyrimid-2-yl)-benzoic acid ethyl ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A suspension of 0.1 mole of 4-amidino-benzoic acid ethyl ester hydrochloride, 0.1 mole of 2-n-heptyl-3-ethoxy-acrolein and 0.14 mole of sodium ethylate in 100 ml. of methanol is stirred overnight at room temperature under an atmosphere of nitrogen. After the usual work up and separation into basic and acidic fractions, there is obtained 4(4-n-heptylpyrimid-2-yl)-benzoic acid ethyl ester and 4-(4-n-heptylpyrimid-2-yl)-benzoic acid.

후처리

  1. customAfter the usual work up and separation into basic and acidic fractions

출처 및 근거

ORD 기록
ord-02baf3ecd7674999909516370f1fd164
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04066570

반응 노트

불러오는 중…