4-Amidinobenzamide Hydrochloride → HCID 13980725, 화합물

HRID 1833719노트

반응식

HRID 1833719 반응식
Cl.[C:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH2:11])=O)=[CH:7][CH:6]=1)(=[NH:4])[NH2:3].[CH2:14]([C:20](=[CH:23]OCC)[CH:21]=O)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].C[O-].[Na+].C(C1C=CN=C(C2C=CC(C(N)=O)=CC=2)N=1)CCCCC>CCOCC.CO>[CH2:14]([C:20]1[CH:21]=[N:3][C:2]([C:5]2[CH:13]=[CH:12][C:8]([C:9]#[N:11])=[CH:7][CH:6]=2)=[N:4][CH:23]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

참가 물질

7

반응물 4

HCID 27242934-Amidinobenzamide HydrochlorideHCID 10942334Sodium MethoxideHCID 541836714-(4-n-Hexylpyrimid-2-yl)benzoic acid amideHCID 542364922-n-Hexyl-3-ethoxy-acrolein

생성물 1

HCID 13980725HCID 13980725, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

0.082 mol. of 4-amidino-benzoic acid amide hydrochloride, suspended in a solution of 0.082 mol. of 2-n-hexyl-3-ethoxy-acrolein and 0.14 mol. of sodium methylate in 150 ml. of methanol, are stirred overnight under an atmosphere of nitrogen at room temperature. The precipitate obtained by dilution of the mixture with 3 liters of ether is removed by filtration, washed with water until neutral and dried at 40° C. in a vacuum drying cupboard, whereby there are obtained 17.9 g. of 4-(4-n-hexylpyrimid-2-yl)-benzoic acid amide; melting point 231.6°-233.0° C.

후처리

  1. customis removed by filtration
  2. washwashed with water until neutral and
  3. customdried at 40° C. in a vacuum
  4. customdrying cupboard, whereby there
  5. customare obtained 17.9 g

출처 및 근거

ORD 기록
ord-b907bcba3d7842af9e7f22903920fa86
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04066570

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