Triethylamine → N-Ethenyl-5-ethoxy-3-oxo-1,2,4-thiadiazole-2(3H)-carboxamide
반응식
C(N(CC)CC)C.[OH:8][C:9]1[N:13]=[C:12]([O:14][CH2:15][CH3:16])[S:11][N:10]=1.[CH:17]([N:19]=[C:20]=[O:21])=[CH2:18]>C(OC(C)C)(C)C>[CH:17]([NH:19][C:20]([N:10]1[C:9](=[O:8])[N:13]=[C:12]([O:14][CH2:15][CH3:16])[S:11]1)=[O:21])=[CH2:18]참가 물질
5
반응 조건
- 온도
- 20 °C
실험 절차
1 ml of triethylamine was added to a solution of 14.6 g of 3-hydroxy-5-ethoxy-1,2,4-thiadiazole in 250 ml of isopropyl ether and after 5 minutes, 8 g of vinyl isocyanate were added. The mixture was stirred for 30 minutes at 20° C and was vacuum filtered and the recovered precipitate was washed, dried and crystallized from ethyl acetate to obtain 15 g of 2-(N-vinylcarbamoyl)-5-ethoxy-1,2,4-thiadiazole-3-one melting at 123° C.
후처리
- filtrationfiltered
- washthe recovered precipitate was washed
- customdried
- customcrystallized from ethyl acetate
출처 및 근거
- ORD 기록
- ord-916ac876808f43549d0b8f5cf3f1cd44
- 출처 데이터셋
- uspto-grants-1978_01
- 특허 번호
- US04067720
반응 노트
불러오는 중…