참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Pyridazine-3-carboxylic acid | HCID 269369 | — |
| 용매 | P-Cymene | HCID 7463 | — |
| 생성물 | (+/-) 3-alpha-Hydroxybenzylpyridazine | HCID 10397539 | 18.6% |
반응 단계
Pyridazine-3-carboxylic acid [prepared as described by Leanza, Becker and Rogers, J.A.C.S., 75, 4086 (1953); 18.6 g.] was mixed with benzaldehyde (44 g.) and p-cymene (360 ml.) and decarboxylated by heating for 3 hours at 135° C. The hot solution was then filtered, cooled and the precipitate collected to give (±) 3-α-hydroxybenzylpyridazine (5.2 g.), m.p. 130°-135° C., in the form of fawn coloured needles.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04067723 |
|---|
| 출처 데이터셋 | uspto-grants-1978_01 |
|---|
| ORD ID | ord-e92ba4ad06404f609a6584063ce73fb4 |
|---|
| 출처 메모 | uspto-grants-1978_01 |
|---|
