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2-Phenylethanol → Benzeneethanamine, N-ethyl-N-phenyl-

HRID 1833984
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HRID 1833984 반응식
[CH2:1]([NH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:2].[C:10]1([CH2:16][CH2:17]O)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.P(OC1C=CC=CC=1)(OC1C=CC=CC=1)OC1C=CC=CC=1>O>[CH2:1]([N:3]([CH2:17][CH2:16][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:2]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 60542-PhenylethanolHCID 7540Triphenyl phosphiteHCID 7670N-Ethylaniline

생성물 1

HCID 3808329Benzeneethanamine, N-ethyl-N-phenyl-수율 81%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
243 °C

실험 절차

182 parts of N-ethylaniline, 244 parts of phenylethyl alcohol and 20 parts of triphenyl phosphite are mixed whilst stirring and next heated to an internal temperature of 206° C, at which the elimination of water commences. The mixture is then heated to an internal temperature of 243° C in the course of 20 hours. During this time, 25 parts of water have distilled off and the condensation has ended. The excess ethylaniline and the unconverted alcohol are then distilled off. 274 parts of N-ethyl-N-phenylethyl-aniline, corresponding to a yield of 81% of theory, distil at a boiling point of 160° C/5 mm Hg.

후처리

  1. distillationDuring this time, 25 parts of water have distilled off
  2. distillationThe excess ethylaniline and the unconverted alcohol are then distilled off
  3. custom274 parts of N-ethyl-N-phenylethyl-aniline, corresponding to a yield of 81% of theory, distil at a boiling point of 160° C/5 mm Hg

출처 및 근거

ORD 기록
ord-d10c9fb8df8d4d7db38508085dfec76f
출처 데이터셋
uspto-grants-1978_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04067903

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