Dichloromethane → HCID 70617081, 화합물

HRID 1834073노트

반응식

HRID 1834073 반응식
Cl[CH2:2]Cl.[CH3:4][C:5]([O:7][CH2:8][C:9]1[CH2:28][S:27][C@@H:12]2[C@H:13]([NH:16][C:17]([C@H:19]([NH2:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:29]([OH:31])=[O:30])=[O:6].O.S([O-])([O-])(=O)=O.[Mg+2]>C(N(CC)CC)C>[CH3:4][C:5]([O:7][CH2:8][C:9]1[CH2:28][S:27][C@@H:12]2[C@H:13]([NH:16][C:17]([C@H:19]([NH2:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:29]([OH:31])=[O:30])=[O:6].[CH2:14]([N:11]([CH2:10][CH3:29])[CH2:12][CH3:2])[CH3:13]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 24083Sulfuric acid magnesium salt (1:1)HCID 7061048122202-75-1

생성물 1

HCID 70617081HCID 70617081, 화합물

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

In 100 ml. of dichloromethane was suspended 4.25 g. of cephaloglycin monohydrate and then 2.8 ml. of triethylamine was dissolved therein. Furthermore, 5 g. of anhydrous magnesium sulfate was added to the system and after stirring the mixture for about 10 minutes at room temperature, the mixture was filtered to provide a solution of cephaloglycin triethylamine salt. The solution was cooled to -20° C. and the suspension of 4-hydroxynicotinoyl chloride prepared above was added dropwise to the solution with stirring. Thereafter, the cooling bath was removed to raise the temperature up to room temperature and the mixture was stirred for about one hour at room temperature.

후처리

  1. filtrationthe mixture was filtered

출처 및 근거

ORD 기록
ord-a1409db2d051446d9c3477cd020e6abc
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04068074

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