Dichloromethane → Cephaloglycin

HRID 1834075노트

반응식

HRID 1834075 반응식
C(Cl)Cl.[CH3:4][C:5]([O:7][CH2:8][C:9]1[CH2:28][S:27][C@@H:12]2[C@H:13]([NH:16][C:17]([C@H:19]([NH2:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:29]([OH:31])=[O:30])=[O:6].O.S([O-])([O-])(=O)=O.[Mg+2]>C(N(CC)CC)C>[CH3:4][C:5]([O:7][CH2:8][C:9]1[CH2:28][S:27][C@@H:12]2[C@H:13]([NH:16][C:17]([C@H:19]([NH2:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:29]([OH:31])=[O:30])=[O:6]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 24083Sulfuric acid magnesium salt (1:1)HCID 7061048122202-75-1

생성물 1

HCID 19150Cephaloglycin

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

After stirring 35 ml. of a methylene chloride solution containing 2.12 g. of cephaloglycin monohydrate, 1.5 g. of anhydrous magnesium sulfate, and 1.4 ml. of triethylamine for one hour at room temperature, magnesium sulfate was filtered off to provide a solution of triethylamine salt of cephaloglycin. After cooling the solution to -25° C., 816 mg. of 2-imidazolidone-1-carboxylic acid chloride and further 0.3 ml. of triethylamine were added thereto.

후처리

  1. filtrationmagnesium sulfate was filtered off

출처 및 근거

ORD 기록
ord-30755719325545ef874dc2b560e95ab6
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04068074

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