1-[2-(3-Bromophenyl)propyl]-2-(cyclohexylmethyl)piperidine → 2,6-Dichlorobenzaldehyde
반응식
C1(CC2CCCCN2CC(C2C=CC=C([CH:23]([OH:32])[C:24]3[C:29]([Cl:30])=[CH:28][CH:27]=[CH:26][C:25]=3[Cl:31])C=2)C)CCCCC1.C1(CC2CCCCN2CC(C2C=CC=C(Br)C=2)C)CCCCC1.C([Li])CCC>C(OCC)C>[Cl:30][C:29]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:31])[C:24]=1[CH:23]=[O:32]참가 물질
5
실험 절차
2-Cyclohexylmethyl-1-{2-[3-(α-hydroxy-2,6-dichlorobenzyl)phenyl]propyl}piperidine (yellow oil) prepared by reaction of 18.9 g. (0.05 mole) of 2-cyclohexylmethyl-1-[2-(3-bromophenyl)-propyl]piperidine with 0.1 mole of butyl lithium in diethyl ether followed by 19.2 g. (0.11 mole) of 2,6-dichlorobenzaldehyde to give 19.3 g. of product.
출처 및 근거
- ORD 기록
- ord-79510472b67f420db07d26455b1d2f9e
- 출처 데이터셋
- uspto-grants-1978_01
- 특허 번호
- US04069256
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