Isopropylamine → Methyl 5-oxo-1-(propan-2-yl)pyrrolidine-3-carboxylate

HRID 1834806노트

반응식

HRID 1834806 반응식
[CH:1]([NH2:4])([CH3:3])[CH3:2].[CH3:5][O:6][C:7](=[O:14])[C:8]([CH2:10][C:11](O)=[O:12])=[CH2:9]>C(OCC)C>[C:7]([CH:8]1[CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[C:11](=[O:12])[CH2:10]1)([O:6][CH3:5])=[O:14]

참가 물질

4

반응물 2

HCID 6363IsopropylamineHCID 4613903Butanedioic acid, 2-methylene-, methyl ester

생성물 1

HCID 20372066Methyl 5-oxo-1-(propan-2-yl)pyrrolidine-3-carboxylate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

In the course of 30 minutes, 59.1 g (1 mol) of isopropyl amine were added dropwise to 158 g (1 mol) of itaconic acid methyl ester in 120 ml of diethyl ether. When the slightly exothermic reaction had finished, the reaction mixture was allowed to stand for 24 hours at room temperature. Then the solvent was removed in vacuo and the residue was subjected to fractionated vacuum distillation. boiling point: 95-98° C/0.05 mm Hg; nD20 : 1.4680

후처리

  1. customWhen the slightly exothermic reaction
  2. customThen the solvent was removed in vacuo
  3. distillationthe residue was subjected to fractionated vacuum distillation

출처 및 근거

ORD 기록
ord-301cc6f27425430e92edf203c395480a
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04071530

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