p-Toluenesulfonic acid → 3-(1,1-Dimethoxyethyl)hept-5-yn-2-one

HRID 1834810노트

반응식

HRID 1834810 반응식
[C:1]([CH:4]([CH2:8][C:9]#[C:10][CH3:11])[C:5](=[O:7])[CH3:6])(=[O:3])[CH3:2].[CH3:12][O:13]C(OC)(C)C.[C:19]1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH3:19][O:7][C:5]([O:13][CH3:12])([CH:4]([C:1](=[O:3])[CH3:2])[CH2:8][C:9]#[C:10][CH3:11])[CH3:6]

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 64952,2-DimethoxypropaneHCID 203721333-(But-2-yn-1-yl)pentane-2,4-dione

생성물 1

HCID 203721323-(1,1-Dimethoxyethyl)hept-5-yn-2-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 38.0 g. (0.25 mol.) of 3-acetyl-5-heptyn-2-one, 32.3 g. (0.31 mol.) of 2,2-dimethoxy-propane, and 5 mg. of p-toluenesulfonic acid in 25 ml. of absolute methanol and 25 ml. of benzene was slowly distilled until the material boiling below 65° had been removed, then stirred with 1 g. of sodium carbonate and filtered to produce 2,2-dimethoxy-3-acetyl-5-heptyne in the filtrate.

후처리

  1. distillationof benzene was slowly distilled until the material
  2. customboiling below 65°
  3. customhad been removed
  4. filtrationof sodium carbonate and filtered

출처 및 근거

ORD 기록
ord-f9fd70a35efa4ca684fc55c1f83bf2b9
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04071542

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