Sodium Carbonate → 17beta-Hydroxy-1alpha-methyl-4-androsten-19-one

HRID 1834922노트

반응식

HRID 1834922 반응식
C(O)(=O)CC.[OH:6][C@H:7]1[CH2:12][CH2:11][C@H:10]2[C@H:13]3[C@H:24]([CH2:25][CH2:26][C@:8]12[CH3:9])[C@:21]1([CH:22]=[O:23])[C:16](=[CH:17][CH2:18][CH2:19][C@@H:20]1[CH3:27])[CH2:15][CH2:14]3.C(=O)([O-])[O-].[Na+].[Na+]>CO>[OH:6][C@H:7]1[CH2:12][CH2:11][C@H:10]2[C@H:13]3[C@H:24]([CH2:25][CH2:26][C@:8]12[CH3:9])[C@:21]1([CH:22]=[O:23])[C:16](=[CH:17][CH2:18][CH2:19][C@@H:20]1[CH3:27])[CH2:15][CH2:14]3

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 8673473517beta-Hydroxy-1alpha-methyl-4-androsten-19-one propionate

생성물 1

HCID 8673473617beta-Hydroxy-1alpha-methyl-4-androsten-19-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 17β-hydroxy-1α-methyl-4-androsten-19-one propionate and sodium carbonate in aqueous methanol is refluxed under nitrogen for approximately 2 hours and poured onto water. The oil which forms is extracted with ether. The ether extract is washed with water, dried over sodium sulfate, and concentrated under reduced pressure. The residue which remains is eluted from silica gel with benzene and crystallized from hexane to yield 17β-hydroxy-1α-methyl-4-androsten-19-one.

후처리

  1. additionpoured onto water
  2. extractionThe oil which forms is extracted with ether
  3. extractionThe ether extract
  4. washis washed with water
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated under reduced pressure
  7. washThe residue which remains is eluted from silica gel with benzene
  8. customcrystallized from hexane

출처 및 근거

ORD 기록
ord-ae87a0f56cc24bedbfbcfc114659ac5b
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04071624

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