17beta,19-Dihydroxy-1alpha,7alpha-dimethyl-4-androsten-3-one → 1alpha,7alpha-Dimethyl-4-androstene-3,17,19-trione

HRID 1834944노트

반응식

HRID 1834944 반응식
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]2[C@H:8]3[C@H:19]([CH2:20][CH2:21][C@:3]12[CH3:4])[C@:16]1([CH2:17][OH:18])[C:11](=[CH:12][C:13](=[O:23])[CH2:14][C@@H:15]1[CH3:22])[CH2:10][C@H:9]3[CH3:24].CC(C)=O.OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[CH3:22][C@@H:15]1[C@@:16]2([CH:17]=[O:18])[C:11]([CH2:10][C@@H:9]([CH3:24])[C@@H:8]3[C@@H:19]2[CH2:20][CH2:21][C@@:3]2([CH3:4])[C@H:5]3[CH2:6][CH2:7][C:2]2=[O:1])=[CH:12][C:13](=[O:23])[CH2:14]1

참가 물질

4

반응물 2

HCID 7058545317beta,19-Dihydroxy-1alpha,7alpha-dimethyl-4-androsten-3-oneHCID 131709961Jones' reagent

생성물 1

HCID 538793401alpha,7alpha-Dimethyl-4-androstene-3,17,19-trione

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

To a solution of 17β,19-dihydroxy-1α,7α-dimethyl-4-androsten-3-one in acetone at 20° C. is added two equivalents of Jones Reagent and the mixture stirred for 30 minutes. The acetone layer is poured onto water with vigorous stirring. The crystals are removed by suction filtration and air dried. Crystallization from an acetone-hexane solution yields 1α,7α-dimethyl-4-androstene-3,17,19-trione.

후처리

  1. customThe crystals are removed by suction filtration and air
  2. customdried
  3. customCrystallization from an acetone-hexane solution

출처 및 근거

ORD 기록
ord-04ef2f3a3ccf481b9aa6bcead4125467
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04071624

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