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Potassium Carbonate → N-(1-methyl-2-oxo-propyl)-N-(3-nitrophenyl)formamide

HRID 1835473
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HRID 1835473 반응식
[CH:1]([NH:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[CH:5]=1)=[O:2].C(=O)([O-])[O-].[K+].[K+].Br[CH:20]([C:22](=[O:24])[CH3:23])[CH3:21]>CN(C)C=O.C(OCC)(=O)C>[CH3:21][CH:20]([N:3]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[CH:5]=1)[CH:1]=[O:2])[C:22](=[O:24])[CH3:23]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 131422-Butanone, 3-bromo-HCID 5971093'-Nitroformanilide

생성물 1

HCID 23503659N-(1-methyl-2-oxo-propyl)-N-(3-nitrophenyl)formamide수율 100%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate
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용매

실험 절차

To a suspension of N-formyl-3-nitroaniline (831 mg) and potassium carbonate (830 mg) in N,N-dimethylformamide (5 ml) was added 2-bromo-3-butanone (906 mg), and the mixture was stirred for 72 hours. The mixture was diluted with ethyl acetate and washed with water and brine. The mixture was dried over magnesium sulfate and evaporated to give N-(1-methyl-2-oxo-propyl)-N-(3-nitrophenyl)formamide (1.18 g, 100%).

후처리

  1. washwashed with water and brine
  2. dry with materialThe mixture was dried over magnesium sulfate
  3. customevaporated

출처 및 근거

ORD 기록
ord-22696cb5901b4df58d51f920ec8970f5
출처 데이터셋
uspto-grants-2004_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06770667B1

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